1) The Brexit process, initiated by the United Kingdom's referendum in 2016, led to the country's withdrawal from the European Union in 2020, marking a significant political and economic change for both the UK and the EU.

2) The musical "Les Misérables" is one of the longest-running shows in the West End and Broadway, with over 13,000 performances.

3) The Industrial Revolution, which began in the 18th century, brought about significant changes in agriculture, manufacturing, mining, and transportation.

4) The concept of self-driving cars, or autonomous vehicles, is being actively developed by companies such as Tesla, Google (Waymo), and Uber.